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城市微生物组和抗菌素耐药性的全球基因组图

David Danko¹, Daniela Bezdan², Evan E Afshin¹

¹Weill Cornell Medicine, New York, NY, USA; The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY, USA.

|May 27, 2021

概括

这项研究绘制了大众交通系统中的全球城市微生物群,揭示了60个城市的不同微生物群落和抗菌药物耐药性标记. 这些发现有助于了解公共卫生和法医应用.

科学领域:

微生物学
基因组学
城市生态

背景情况:

城市环境中存在复杂的微生物生态系统.
了解公共空间的微生物成分对于公共健康至关重要.
转基因组分析为研究微生物群体提供一种独立于培养的方法.

研究的目的:

在大众运输系统中创建微生物生命的全面全球地图.
在全球范围内描述微生物菌株,功能基因和抗菌素耐药性 (AMR) 标志物.
识别不同的城市微生物特征及其驱动因素.

主要方法:

在60个城市收集了4728个基因组样本.
分析了微生物组成,包括病毒,细菌,古生物和CRISPR阵列.
在地理空间上绘制了微生物数据,并确定了AMR基因和新型遗传元素.

主要成果:

创建了4728个元基因组样本的全球地图,对城市微生物生态系统进行了目录.
在 97% 的样本中发现了 4,246 种已知的城市微生物和 31 种核心物种.
发现了与气候和地理相关的抗菌性基因特征和不同城市的微生物特征的显著变异.

结论:

全球元基因组图谱提供了城市微生物多样性和抗菌耐药性的高分辨率视图.
这些发现突出了在公共卫生,法医和了解抗药物负担方面的潜在应用.
这项研究提供了一个文化独立的城市微生物组视角.

关键词:

抗菌药物美国没有NGS 抗微生物耐药性建筑环境一个新的组装全球卫生转基因组微生物组猎枪测序

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