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Updated: Aug 13, 2026

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
14:23

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

Published on: August 31, 2014

人类免疫缺陷病毒类型-1的广泛变异 in vivo

M S Saag1, B H Hahn, J Gibbons

  • 1Department of Internal Medicine, University of Alabama, Birmingham 35294.

Nature
|August 4, 1988
PubMed
概括

人类免疫缺陷病毒1型 (HIV-1) 在慢性感染期间体内表现出快速的基因型变异. 多种相关的病毒基因型在个体内共存,挑战了HIV-1分离体的定义.

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Viral Mutations00:36

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material for adaptive...