这页已由机器翻译。其他页面可能仍然显示为英文。View in English
来自克里米亚-刚果出血热患者的保护性中和抗体
J Maximilian Fels1, Daniel P Maurer2, Andrew S Herbert3
1Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Cell
|June 2, 2021
在PubMed 上查看摘要
概括
研究人员发现了针对克里米亚 - 刚果出血热病毒 (CCHFV) 的强效中和单克隆抗体 (nAbs). 一个双特异性抗体 (bsAb),DVD-121-801,在小鼠中显示出治疗性保护,显示出对CCHFV治疗的希望.
科学领域:
- 病毒学
- 免疫学
- 传染性疾病
背景情况:
- 克里米亚 - 刚果出血热病毒 (CCHFV) 是致死性出血热的高优先病原体.
- 迫切需要有效的治疗和疫苗来对抗CCHFV.
研究的目的:
- 描述人类对CCHFV感染的免疫反应.
- 确定向CCHFV糖蛋白的强中和单克隆抗体 (nAbs).
- 开发针对CCHFV的新疗法.
主要方法:
- 人类对CCHFV感染的免疫反应的特征.
- 针对CCHFV糖蛋白 (Gc) 的nAbs的鉴定和竞争分析.
- 突变发生,结构映射和双特异抗体 (bsAb) 工程.
主要成果:
- 确定了nAbs与CCHFV Gc亚单元的六个不同的抗原位点结合.
- 通过非竞争性nAbs的组合发现了协同中和.
- 工程 bsAbs 增强的中和宽度和功率.
- 在多个nAbs的小鼠中证明了预防性保护.
- 通过bsAb DVD-121-801展示了对致命CCHFV的治疗性保护.
相关概念视频
00:42Cross-reactivity
31.9K
Overview
31.9K
01:29Immune Response Against Viral Pathogens
1.2K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.2K