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Updated: Nov 3, 2025

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
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在T细胞信号传输中,T细胞受体对MHC接是必不可少的

Pirooz Zareie1, Christopher Szeto1, Carine Farenc1

  • 1Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

Science (New York, N.Y.)
|June 4, 2021
PubMed
概括

T细胞受体 (TCR) 的对接极性对于T细胞激活至关重要,而不仅仅是识别. 反向TCR对接通过错误定位Lck等关键蛋白质来阻止T细胞信号传递,突出显示信号限制.

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