在初级嗅觉皮层的表现漂移
Carl E Schoonover1, Sarah N Ohashi2,3, Richard Axel4
1Howard Hughes Medical Institute, Mortimer B. Zuckerman Mind Brain Behavior Institute, Department of Neuroscience, Columbia University, New York, NY, USA. ces2001@columbia.edu.
Nature
|June 10, 2021
概括
嗅觉皮层对气味的反应是不稳定的, 皮质皮质的这种不稳定性挑战其在稳定嗅觉中的作用,并且可能在其他大脑区域中很常见.
科学领域:
- 神经科学
- 嗅觉系统研究
- 感官感知
背景情况:
- 感知常数依赖于大脑对感觉输入的稳定表现.
- 人们认为皮质皮质 (嗅觉皮质) 编码着气味的特征.
研究的目的:
- 在长时间内研究小鼠皮质中气味引起的神经反应的稳定性.
- 为了确定恐惧条件或重复的气味暴露能否稳定这些反应.
主要方法:
- 在几周内对小鼠皮质状皮质单个单元的电生理记录.
- 使用线性分类器来评估随时间推移的气味分辨性能.
- 实施恐惧调节和日常气味暴露模式.
主要成果:
- 在状皮质中,气味引起的反应在几天到几周内显著变化.
- 经过初始响应训练的分类器失去了准确性,在32天后接近机会水平.
- 既没有恐惧条件,也没有每天的气味暴露阻止了反应偏移.
结论:
- 皮质皮质显示出持续的气味反应, 质疑其在稳定的气味感知中的作用.
- 这种神经不稳定可能是皮质皮质的非结构性连接的特征.
- 这种不稳定性可能是其他非结构化皮质区域的共同特征.
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