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Updated: Nov 2, 2025

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation
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通过快速光遗传激活向蛋白质降解及其应用于细胞信号的控制

Amy Ryan1, Jihe Liu1, Alexander Deiters1

  • 1Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.

Journal of the American Chemical Society
|June 14, 2021
PubMed
概括

研究人员开发了一种新的光控制系统, 这种方法使用光化降解剂来控制蛋白质水平,使细胞过程的动态研究成为可能.

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Regulated Protein Degradation02:58

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It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
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