免疫球蛋白中的肘部运动涉及一个分子球和口关节
Nature
|September 8, 1988
概括
抗体分子在它们的域之间表现出动态的运动,由特定的蛋白质区域促进. 这些运动涉及分子球关节,对于抗体功能至关重要,并且在相关的免疫受体中得到保护.
科学领域:
- 免疫学 免疫学 免疫学
- 结构生物学 结构生物学
- 生物化学 生物化学
背景情况:
- 免疫球蛋白 (抗体) 分子具有灵活的域,允许运动.
- 这种灵活性对于与抗原和效应蛋白相互作用至关重要.
- 之前的研究发现了链和开关区域的运动,这些区域连接了抗体域.
研究的目的:
- 为了研究免疫球蛋白中VL-VH二元体和CL-CH1二元体之间的运动的结构基础.
- 为了识别涉及域间移动的保存残留物.
- 了解这些运动在抗体结构和功能中的功能意义.
主要方法:
- 使用X射线晶体学分析免疫球蛋白的原子结构.
- 免疫球蛋白结构与不同序列和晶体环境的比较.
- 在域界面上识别保存的氨基酸残留物.
主要成果:
- 在VL-VH二元体和CL-CH1二元体之间的运动涉及一个分子球接头.
- 这个关节是由三个VH和两个CH1残留物之间的特定相互作用形成的.
- 这些相互作用的残留物在免疫球蛋白和T细胞受体中高度保存.
结论:
- 鉴定到的球关节是一个关键的结构特征,使免疫球蛋白能够在免疫球蛋白中进行域间运动.
- 这些残留物的高度保存表明它们在抗体和T细胞受体的功能中起着基本作用.
- 这一发现提供了对免疫受体相互作用背后的分子机制的见解.
相关概念视频
Joints
Joints, also called articulations or articular surfaces, are points at which ligaments or other tissues connect adjacent bones. Joints permit movement and stability, and can be classified based on their structure or function.
Structural joint classifications are based on the material that makes up the joint as well as whether or not the joint contains a space between the bones. Joints are structurally classified as fibrous, cartilaginous, or synovial.
Fibrous Joints Are Immovable
The bones of a...
Structural joint classifications are based on the material that makes up the joint as well as whether or not the joint contains a space between the bones. Joints are structurally classified as fibrous, cartilaginous, or synovial.
Fibrous Joints Are Immovable
The bones of a...
Antibody Structure
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibody Structure
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Bones of the Upper Limb: Humerus
The upper limb consists of the arm, forearm, wrist, and hand bones. The humerus is the single bone of the upper arm region. Proximally, it has a large, spherical, smooth head that articulates with the glenoid cavity of the scapula to form the glenohumeral or shoulder joint. The margin of the head is the anatomical neck, a residual epiphyseal plate. Laterally it extends to form bony projections called the greater tubercle and the lesser tubercle. Next to the tubercles is the surgical neck, a...
Bones of the Upper Limb: Ulna
The ulna and radius are parallel bones of the antebrachium or the forearm. The ulna lies medially and consists of a bony tip called the olecranon process at its proximal end. This hook-like projection articulates with the olecranon fossa of the humerus and forms the "hinged" ulnohumeral part of the elbow joint. This joint facilitates forearm extension and flexion while preventing its hyperextension. Similarly, the coronoid process, another bony projection on the proximal/anterior side of the...
Bones of the Upper Limb: Radius
The radius is longer of the two bones that make up the human antebrachium or forearm. At the proximal end, the radius articulates with the capitulum of the humerus and the radial notch of the ulna to form the elbow joint. At the distal end, the radius articulates with the ulna via the ulnar notch, forming the distal radioulnar joint. Distally, the radius also attaches to the carpal wrist bones (scaphoid and lunate) to form the radiocarpal joint.
The radius has a nail-shaped head, and a short...
The radius has a nail-shaped head, and a short...


