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相关概念视频

Cell Migration01:19

Cell Migration

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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Cell Migration01:09

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Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
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The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
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In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
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The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
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相关实验视频

Updated: Nov 2, 2025

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification
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Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification

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由细胞矩阵驱动的芽表皮形态与细胞对细胞粘附

Shaohe Wang1, Kazue Matsumoto1, Samantha R Lish2

  • 1Cell Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

Cell
|June 16, 2021
PubMed
概括
此摘要是机器生成的。

在器官发育中至关重要的层次上皮质芽是由特定的细胞粘附特性驱动的. 在外围细胞中强大的细胞矩阵和弱的细胞粘附使这一关键步骤成为可能.

关键词:
其他:分支形态发生芽形态发生细胞对细胞的粘附细胞矩阵粘附不同的粘合力表皮形态发生综合素唾液腺组织工程

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Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification

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Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

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科学领域:

  • 发育生物学
  • 细胞生物学
  • 生物物理

背景情况:

  • 皮质形态发生对于形成唾液腺和胰腺等复杂器官至关重要.
  • 在分层上皮质中驱动芽和分支的机制尚未完全理解.

研究的目的:

  • 在胚胎器官发育过程中阐明分层上皮质芽的细胞和分子驱动因素.
  • 研究细胞粘附在启动分支形态发生中的作用.

主要方法:

  • 在单细胞分辨率下对小鼠胚胎唾液腺体进行活体器官成像.
  • 单细胞转录组分析以确定空间基因表达模式.
  • 用实验性操纵细胞粘附分子 (E-cadherin) 和底层膜诱导的3D球形培养.

主要成果:

  • 胚芽形态发生是由具有强大的细胞矩阵和弱细胞粘附的上皮细胞驱动的.
  • 空间转录模式与观察到的细胞粘附差异相关.
  • 合成复制证实抑制的E-cadherin和诱导的基底膜,与β1-整合素信号,使得芽.

结论:

  • 层状上皮芽是由具有差异粘附性质的独特细胞板启动的.
  • 强大的细胞矩阵粘附和弱的细胞粘附对于分支形态的初始芽阶段至关重要.
  • 这项研究提供了对上皮细胞芽的机理理解,