喷反射是由从鼻子到大脑干的体路径介导的
Fengxian Li1, Haowu Jiang1, Xiaolei Shen1
1Department of Anesthesiology, Center for the Study of Itch and Sensory Disorders, and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO 63110, USA.
Cell
|June 16, 2021
概括
科学家们发现了的新神经通道. 通过脑干中对NMB敏感的神经元发出信号,触发这种重要的呼吸反射.
科学领域:
- 神经科学
- 呼吸系统生理学
- 分子生物学
背景情况:
- 打喷是一个关键的反射,
- 控制打喷的精确神经回路在很大程度上是未知的.
- 之前的研究发现了脑干中引起喷的区域.
研究的目的:
- 解释反应背后的神经回路和分子机制.
- 确定涉及到将鼻腔传感信息传递到脑干的特定神经递质.
- 研究神经美丁B (NMB) 在打喷中扮演的角色.
主要方法:
- 通过鼻腔感觉神经元释放的神经递质/神经的查.
- 在动物模型中对NMB敏感神经元的切除和NMB受体缺陷研究.
- 从喷引发区域的神经元突出的解剖学追踪.
- 特定神经元群体的电生理记录和化学激活.
主要成果:
- 神经乙基 (NMB) 被确定为打喷信号的关键.
- 切除对NMB敏感的神经元或阻断NMB受体可以消除喷反射.
- 对NMB敏感的神经元向尾部腹部呼吸群 (cVRG) 发射.
- 这些神经元的激活诱导了cVRG神经元的动作潜力并触发了打喷.
结论:
- 一个涉及NMB的新型体路径调解了打喷反射.
- 这一途径涉及脑干中向cVRG投射的NMB敏感神经元.
- 这些发现为反应弧的神经生物学提供了关键的分子见解.
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