相关实验视频
Updated: Nov 2, 2025

09:01
A Macrophage-Tumor Spheroid Co-Invasion Assay
Published on: January 24, 2025
870
组织寄存的巨细胞为早期的NSCLC细胞提供了前瘤位
María Casanova-Acebes1,2,3,4, Erica Dalla5,6,7,8, Andrew M Leader9,10,11
1Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. mcasanova@cnio.es.
Nature
|June 17, 2021
概括
组织寄存的巨细胞通过帮助瘤的侵袭性和免疫逃避,促进早期的肺癌. 针对这些巨细胞可能是预防和治疗早期肺癌的新策略.
科学领域:
- 免疫学
- 癌症学
- 细胞生物学
背景情况:
- 巨细胞在瘤微环境 (TME) 中起着至关重要的作用,影响瘤免疫力和对免疫治疗的反应.
- 了解瘤中的巨细胞的多样性对于开发有效的癌症治疗至关重要.
- 巨细胞起源于不同的血统:自我更新的组织居民巨细胞和短命的单细胞衍生巨细胞.
研究的目的:
- 研究人类非小细胞肺癌 (NSCLC) 瘤中巨细胞群的多样性和起源.
- 阐明组织居民和单细胞衍生的巨细胞在早期肺癌进展中的不同作用.
- 在巨细胞区内确定早期肺癌的潜在治疗点.
主要方法:
- 来自人类NSCLC病变的瘤相关白细胞的单细胞RNA测序.
- 在小鼠模型中追踪血统,以确定巨的起源和分布.
- 功能性研究涉及组织寄存巨细胞的消耗.
主要成果:
- 在人类和小鼠肺部瘤中发现了不同的巨细胞群,它们在TME内的起源和分布有所不同.
- 组织寄存的巨细胞在瘤发育的早期积聚,促进瘤细胞的侵入性,并通过调节性T细胞抑制适应性免疫力.
- 组织内巨细胞的消耗减少了调节性T细胞,增强了CD8+T细胞的积累,并降低了瘤的生长和侵入性.
- 单细胞衍生的巨细胞在NSCLC的后期阶段变得主导,组织寄存的巨细胞重新分布到瘤外围.
结论:
- 组织寄存的巨细胞是早期肺癌发展和进展的关键驱动因素.
- 这些巨细胞促进瘤的侵入性和免疫逃避,使它们成为早期NSCLC的有希望的治疗点.
- 向组织寄存的巨细胞为预防和治疗早期肺癌病变提供了一种新的策略.
相关概念视频
The Tumor Microenvironment
7.1K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.1K
Immune Surveillance by NK Cells and Phagocytes
6.5K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
6.5K
Stem Cell Niche
5.6K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.6K
Metastasis
5.9K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.9K
Cancer Stem Cells and Tumor Maintenance
5.2K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.2K

