双菌介导的免疫系统在生命早期形成
Bethany M Henrick1, Lucie Rodriguez2, Tadepally Lakshmikanth2
1Evolve BioSystems, Inc., Davis, CA 95618, USA; Department of Food Science and Technology, University of Nebraska, Lincoln, Lincoln, NE 68588-6205, USA.
Cell
|June 18, 2021
概括
早期有益的细菌,如Bifidobacterium infantis,对于免疫系统的发展至关重要. 补充剂可以减少婴儿的炎症和免疫失调,促进更健康的免疫反应.
科学领域:
- 微生物学
- 免疫学
- 人类健康
背景情况:
- 早期免疫与微生物的相互作用会影响长期健康,
- 哺乳促进有益的微生物群落和宿主免疫系统的发展.
- 某些有益的细菌,如双菌,在现代社会中正在减少.
研究的目的:
- 调查双菌,特别是它们的人类牛奶寡糖化物 (HMO) 利用基因与早期免疫状况之间的联系.
- 确定婴儿补充Bifidobacterium infantis EVC001对免疫反应的影响.
主要方法:
- 分析基因组数据以评估HMO利用基因的存在.
- 临床研究涉及母乳养婴儿补充了Bifidobacterium infantis EVC001.
- 测量肠道细胞因子 (Th2,Th17) 和干扰素β (IFNβ).
- 便水代谢物的分析,包括甲酸和甲酸 (ILA).
主要成果:
- 肠道微生物组中HMO利用基因的耗尽与全身炎症和免疫失调有关.
- 用Bifidobacterium infantis EVC001补充剂使肠道Th2和Th17细胞因子沉默,并诱导IFNβ.
- 在特定的T细胞群体中,婴儿肠道细菌衍生的乳酸和ILA提高了免疫调节力.
结论:
- 双细菌在生命早期的免疫稳定中起着至关重要的作用.
- 使用HMO的细菌对于预防免疫失调和炎症至关重要.
- 像ILA这样的微生物代谢物对婴儿有有益的免疫调节作用.
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