在体内对SARS-CoV-2变种菌株的单克隆抗体有效性
Rita E Chen1,2, Emma S Winkler1,2, James Brett Case1
1Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.
Nature
|June 21, 2021
概括
单克隆抗体 (mAb) 组合在体内显示出对SARS-CoV-2变体的显著保护,尽管体内有一些功效损失. 许多抗体对抗措施对新出现的菌株仍然有效.
科学领域:
- 病毒学
- 免疫学
- 药理学
背景情况:
- 新出现的SARS-CoV-2变种对基于抗体的疗法构成威胁.
- 在体外研究表明抗体对变体的效能降低,但体内相关性尚不清楚.
研究的目的:
- 评估单克隆抗体 (mAbs) 对SARS-CoV-2变种的体外和体内疗效.
- 评估新兴菌株抗体强度变化的临床相关性.
主要方法:
- 在细胞培养和动物模型中对mAbs组进行了测试 (K18-hACE2转基因小鼠,129S2小鼠,仓鼠).
- 评估了mAbs的预防和感染后使用情况.
主要成果:
- 一些单个mAbs在体外失去了对E484突变的变体的中和活性.
- 低剂量的mAb组合在体内保护多种变体而没有耐药性.
- 某些单一疗法和组合疗法 (LY-CoV555,AbbVie 2B04/47D11) 的疗效降低或丧失.
- 一些mAb尾酒的较高剂量在感染后对B.1.351变种进行了保护.
结论:
- 许多抗体产品对盛行的SARS-CoV-2变种保持了显著的有效性.
- mAb组合通常在体内有效,提供对变种菌株的保护.
- 特定抗体疗法对某些新出现的变体可能效果较差.
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