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Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining
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Ad26.COV2.S对的SARS-CoV-2 B.1.351的保护性有效性

Jingyou Yu1, Lisa H Tostanoski1, Noe B Mercado1

  • 1Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Nature
|June 23, 2021
PubMed
概括

Ad26.COV2.S 疫苗显示出对B.1.351等SARS-CoV-2变种的保护. 虽然抗体反应较低,但T细胞反应仍然很强,在 rhesus 中提供了强大的保护.

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Coronavirus01:29

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Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...