基因的降解性脱碳功能化
Qi Pan1, Yuanyuan Ping1, Yifan Wang1
1The Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, People's Republic of China.
Journal of the American Chemical Society
|June 24, 2021
概括
这项研究引入了一种新的催化剂控制的二碳功能化方法. 它使有价值的合乳酸与四元中心的区域分离合成成为可能,克服了以前的循环选择性限制.
科学领域:
- 有机化学
- 催化剂
- 合成方法
背景情况:
- 过渡金属催化使得二碳功能化能够构建复杂的异环.
- 之前的方法仅限于外选择性循环/交叉合,阻碍了对内选择性产品的获取.
- 在异态循环中合成固态拥挤的四元碳中心仍然是一个挑战.
研究的目的:
- 开发第一个由催化剂控制的,区域分离的二碳功能化.
- 为了实现四元中心的五元和六元合乳酸盐的选择性合成.
- 通过分子间交叉合后的Heck循环检测证明了对分子内区域选择性的连接体控制.
主要方法:
- 使用过渡金属催化剂进行二碳功能化.
- 用于5-exo循环/交叉合的Pyrox或Phox型双联体.
- 使用C6-碳酸修饰的2,2'-双连体进行6内选择性循环/交叉合.
主要成果:
- 通过5-exo循环/交叉合实现了五个成员的因多-2-的区域分离合成,具有高产量和反选择性 (高达98% ee).
- 通过6-endo循环/交叉合合成了六个组成的3,4-二二,产量良好.
- 证明了连体选择,而不是基质结构,决定了区域选择性模式.
- 展示了开发的协议的模块化和功能组宽容性.
结论:
- 报告了第一个由催化剂控制的区域分离二碳功能化的例子.
- 建立了一种用于合成全碳四元中心的合乳酸盐的多功能方法.
- 通过生物相关分子和支架的制备突出了该协议的合成实用性.
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