卡路里限制破坏了微生物群和殖民抵抗力
Reiner Jumpertz von Schwartzenberg1,2,3, Jordan E Bisanz4, Svetlana Lyalina5
1Charité Universitätsmedizin Berlin, Department of Endocrinology and Metabolic Diseases, Berlin, Germany.
Nature
|June 24, 2021
概括
严重的卡路里限制会改变肠道微生物组,影响宿主代谢和营养吸收. 饮食对微生物群的改变会导致体重减轻和改变宿主生理.
科学领域:
- 微生物学
- 人类生理学
- 代谢健康
背景情况:
- 饮食显著影响肠道微生物组合.
- 饮食引起的微生物组改变对宿主健康的影响尚未完全理解.
研究的目的:
- 研究低热量饮食对人类肠道微生物群的影响.
- 用小鼠模型确定饮食诱导的微生物组变化的后果.
主要方法:
- 随机的人类干预研究与非常低卡路里饮食.
- 从人类参与者 (饮食前和饮食后) 移植到无菌小鼠.
- 对宿主体重,脂肪,营养吸收和微生物组成进行评估.
主要成果:
- 严重的卡路里限制减少了细菌的数量,
- 将饮食后的微生物移植给小鼠导致体重减轻和肥胖.
- 在小鼠中,体重减轻与营养吸收受损,Clostridioides difficile的丰富以及胆汁酸的减少有关.
结论:
- 饮食与微生物组的相互作用对于调节宿主能量平衡至关重要.
- 了解饮食在致病和有益微生物之间的相互作用中的作用对于代谢健康至关重要.
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