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Updated: Nov 1, 2025

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从单细胞癌症基因组的时间序列建模推断的克隆适应性

Sohrab Salehi1, Farhia Kabeer1,2, Nicholas Ceglia3

  • 1Department of Molecular Oncology, BC Cancer, Vancouver, British Columbia, Canada.

Nature
|June 24, 2021
PubMed
概括

这项研究揭示了拷贝数的变化如何影响癌症的演变. 在三阴性乳腺癌中,TP53突变和化疗改变了克隆健康动态,影响了治疗耐药性.

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