内生逆转录病毒促进对微生物群的稳定性和炎症反应
Djalma S Lima-Junior1, Siddharth R Krishnamurthy2, Nicolas Bouladoux2
1Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Cell
|June 24, 2021
概括
皮肤微生物群触发内源逆转录病毒 (ERV),激活免疫细胞. 这种受饮食影响的相互作用对宿主免疫力,组织修复和炎症控制至关重要.
科学领域:
- 免疫学
- 微生物学
- 病毒学
背景情况:
- 皮肤微生物群对于宿主免疫力至关重要,但其免疫调节机制尚不清楚.
- 内生逆转录病毒 (ERV) 是宿主基因组的组成部分,其在免疫力中的作用仍在出现.
研究的目的:
- 研究皮肤微生物群通过内源逆转录病毒 (ERV) 调节宿主免疫力的作用.
- 阐明涉及微生物群诱导ERV表达的信号通路和细胞反应.
- 确定ERV活动对免疫反应和组织平衡的影响.
主要方法:
- 分析小鼠的皮肤微生物群和ERV表达.
- 调查涉及循环GMP-AMP合成酶 (cGAS) /干扰素基因蛋白 (STING) 信号的内在基因反应.
- 评估抑制ERV逆转录对免疫反应和组织修复的影响.
- 评估脂质丰富饮食对ERV表达和免疫结果的影响.
主要成果:
- 皮肤微生物群诱导内源性逆转录病毒 (ERV) 在角质细胞中的特异表达.
- ERV反应取决于cGAS/STING信号传递,促进开始性特异性T细胞诱导.
- 抑制ERV逆转录会影响免疫和组织修复功能.
- 富含脂质的饮食会增强ERV的表达,增加免疫反应和炎症.
结论:
- 主体利用其内源病毒组 (ERV) 与外源微生物群进行通信.
- 这种多领域的对话对于平衡组织平衡和炎症至关重要.
- 饮食干预可以调节这种相互作用,影响免疫反应和皮肤健康.
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