SARS-CoV-2 mRNA 疫苗诱导人类生殖中心持续反应
Jackson S Turner1, Jane A O'Halloran2, Elizaveta Kalaidina3
1Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Nature
|June 28, 2021
概括
SARS-CoV-2 mRNA 疫苗诱导长期的生殖中心 B 细胞反应. 这会产生强烈的抗体免疫力,对持续保护COVID-19及其变种至关重要.
科学领域:
- 免疫学
- 疫苗学
背景情况:
- SARS-CoV-2 的 mRNA 疫苗显示出对 COVID-19 的高效.
- 在mRNA疫苗接种后,B细胞反应的精确动态,包括分泌抗体的等离子体和生殖中心B细胞,尚不完全理解.
研究的目的:
- 在BNT162b2 mRNA疫苗接种后,研究周围血液和排水淋巴结中的抗原特异性B细胞动态.
- 描述SARS-CoV-2 mRNA疫苗接种产生的B细胞的表型和抗体结合性质.
主要方法:
- 对接受两剂BNT162b2疫苗的患者的周围血液和细针吸血液的分析.
- 对与SARS-CoV-2尖端 (S) 蛋白结合的循环等离子体和B细胞的量化.
- 来自生殖中心B细胞的单克隆抗体的表征.
主要成果:
- 循环中的S蛋白特异性血清细胞在第二剂后一周达到峰值,并在三周内下降.
- 在初级免疫接种后的淋巴结中检测到结合S蛋白的生殖中心B细胞,并且持续至少12周.
- 来自生殖中心B细胞的单克隆抗体主要向S蛋白的受体结合域,对其他β冠状病毒有一些交叉反应.
结论:
- 在人体中,SARS-CoV-2 mRNA 疫苗引发持续的生殖中心 B 细胞反应.
- 这种持续的生殖中心反应对于产生强大且可能长期存在的针对SARS-CoV-2及其变种的免疫力至关重要.
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