精神分裂症中推断关系的神经重复受损
Matthew M Nour1, Yunzhe Liu2, Atheeshaan Arumuham3
1Max Planck University College London Centre for Computational Psychiatry and Ageing Research, London WC1B 5EH, UK; Wellcome Centre for Human Neuroimaging (WCHN), University College London, London WC1N 3AR, UK; Department of Psychosis Studies, Institute of Psychiatry Psychology and Neuroscience, King's College London, London SE5 8AF, UK.
Cell
|July 1, 2021
概括
精神分裂症患者在休息时会出现神经复杂, 影响他们形成心理图谱的能力. 这种对学习和记忆至关重要的大脑活动与健康个体有很大不同.
科学领域:
- 神经科学
- 认知科学
- 精神病学
背景情况:
- 就像世界模型一样, 结构化的心理表现对于超越直接经验的想象至关重要.
- 在动物中,在休息 (重复) 期间的序列位置细胞重新激活支持了这些表示.
- 精神分裂症被假定涉及受损的结构性心理表现,动物模型显示异常的海马重复和波纹活动.
研究的目的:
- 在需要推断精神分裂症患者对象关系的任务中调查神经重复和海马活动.
- 为了比较精神分裂症患者和健康对照者的神经动态.
主要方法:
- 在精神分裂症患者和对照组中使用磁脑图 (MEG) 来记录大脑活动.
- 参与者通过重新组织视觉体验来推断未被观察到的对象关系.
- 在任务后休息期间分析神经活动,以发现自发的神经重新激活 (重播) 和海马波动力.
主要成果:
- 健康的对照对象表现出呈现物体的快速自发神经重新激活 (重播),反映出推断的关系,与海马波功率的增加相吻合.
- 与对照组相比,精神分裂症患者的神经重播减少,海马波功率增加.
- 这些神经异常与行为获取和任务结构表现受损相关.
结论:
- 对精神分裂症患者的研究结果与动物模型相一致,表明海马体的反复和波动活动异常.
- 在精神分裂症中,神经重复和波纹功率的改变与形成结构化的心理表现和学习的缺陷有关.
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