Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cell Size01:22

Cell Size

Cell sizes vary widely among and within organisms. Bacterial cells range between 1-10 micrometers (μm)and are considerably smaller than most eukaryotic cells. The smallest bacteria are 0.1 μm in diameter—about a thousand times smaller than eukaryotic cells, which typically range from 10-100 μm.
Surface Area
Cells can take in nutrients and water via diffusion through the plasma membrane itself or through specific channels in the membrane. The area of the membrane surrounding the cells limits the...
Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...
Determining the Plane of Cell Division02:13

Determining the Plane of Cell Division

Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Gigabase-scale deletion scanning of the human genome.

bioRxiv : the preprint server for biology·2026
Same author

Embryo-scale Visual Cell Sorting reveals a conserved transcriptomic signature of nucleolar size linked to proteostasis.

bioRxiv : the preprint server for biology·2026
Same author

Organ formation in early human embryos captured in spatial cell atlas.

Nature·2026
Same author

Retracing and rewriting the evolutionary trajectories of mammalian developmental enhancers.

bioRxiv : the preprint server for biology·2026
Same author

Technical and biological sources of noise confound multiplexed enhancer AAV screening.

Nature communications·2026
Same author

Pool-packaged AAV libraries exhibit extensive length-dependent and homology-dependent chimerism.

Nature biotechnology·2026
Same journal

A native sulfur deposit in Gale crater, Mars.

Science (New York, N.Y.)·2026
Same journal

Coordinated demise of harmful algal blooms.

Science (New York, N.Y.)·2026
Same journal

Genetic effects put into context.

Science (New York, N.Y.)·2026
Same journal

Bacteria share proteins to survive antibiotics.

Science (New York, N.Y.)·2026
Same journal

Impacts shaped Earth's first continents.

Science (New York, N.Y.)·2026
Same journal

Erratum for the Report "Covalently bonded single-molecule junctions with stable and reversible photoswitched conductivity" by C. Jia <i>et al</i>.

Science (New York, N.Y.)·2026
查看所有相关文章

相关实验视频

Updated: May 13, 2026

Transcriptome Analysis of Single Cells
07:27

Transcriptome Analysis of Single Cells

Published on: April 25, 2011

30.2K

胚胎规模,单细胞空间转录组学

Sanjay R Srivatsan1, Mary C Regier2,3, Eliza Barkan1,4

  • 1Department of Genome Sciences, University of Washington, Seattle, WA, USA.

Science (New York, N.Y.)
|July 2, 2021
PubMed
概括
此摘要是机器生成的。

新的sci-Space技术通过大面积的高分辨率绘制发育胚胎中的基因表达. 这种方法揭示了解剖学基因模式和细胞行为,促进了发育生物学研究.

更多相关视频

Multiplexed Single Cell mRNA Sequencing Analysis of Mouse Embryonic Cells
08:30

Multiplexed Single Cell mRNA Sequencing Analysis of Mouse Embryonic Cells

Published on: January 7, 2020

13.5K
Author Spotlight: A Pipeline to Analyze Lineage-Specific Mutant Embryos at Single-Cell Resolution
09:14

Author Spotlight: A Pipeline to Analyze Lineage-Specific Mutant Embryos at Single-Cell Resolution

Published on: June 14, 2024

1.3K

相关实验视频

Last Updated: May 13, 2026

Transcriptome Analysis of Single Cells
07:27

Transcriptome Analysis of Single Cells

Published on: April 25, 2011

30.2K
Multiplexed Single Cell mRNA Sequencing Analysis of Mouse Embryonic Cells
08:30

Multiplexed Single Cell mRNA Sequencing Analysis of Mouse Embryonic Cells

Published on: January 7, 2020

13.5K
Author Spotlight: A Pipeline to Analyze Lineage-Specific Mutant Embryos at Single-Cell Resolution
09:14

Author Spotlight: A Pipeline to Analyze Lineage-Specific Mutant Embryos at Single-Cell Resolution

Published on: June 14, 2024

1.3K

科学领域:

  • 发育生物学
  • 基因组学
  • 计算生物学

背景情况:

  • 空间基因表达模式对于发育至关重要,
  • 现有的空间转录学工具在分辨率或视野上有局限性.
  • 了解大规模的空间基因表达是解读发育过程的关键.

研究的目的:

  • 介绍Sci-Space,这是一个用于大面积高分辨率空间转录的新方法.
  • 分析发育小鼠胚胎中的空间基因表达模式和细胞异质性.
  • 能够构建具有空间分辨率的哺乳动物发育单细胞地图.

主要方法:

  • 科学空间技术的发展和应用.
  • 捕获近似的空间坐标和单个核的整个转录.
  • 对基因表达模式,细胞亚型和迁移行为进行分析.

主要成果:

  • sci-Space在更大的尺度上解决了空间异质性,同时保留了单细胞分辨率.
  • 在成长中的小鼠胚胎中, 数以千计的基因表现出解剖学上的模式.
  • 空间信息有助于注释细胞亚型,并揭示了不同细胞类型的空间模式.
  • 发育假时间和神经元迁移模式之间存在关联.

结论:

  • sci-Space克服了以前方法的局限性,使得大规模的空间转录学成为可能.
  • 这项研究为胚胎发育过程中的基因表达模式和细胞动态提供了新的见解.
  • 这项技术将有助于创建具有空间分辨率的发展地图.