通过UVB和MITF独立的机制,NNT调节氧化还原性色素化
Jennifer Allouche1, Inbal Rachmin1, Kaustubh Adhikari2
1Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Cell
|July 7, 2021
概括
一种独立于紫外线和MITF的皮肤颜色的新机制已被发现. 向尼古丁胺核酸转酶 (NNT) 酶会影响皮肤变黑和产生黑色素.
科学领域:
- 遗传学
- 生物化学
- 皮肤病学
背景情况:
- 皮肤颜色是由紫外线和遗传因素决定的.
- 皮肤颜色的MITF独立路径尚未完全理解.
研究的目的:
- 为了阐明皮肤颜色的新机制.
- 研究尼古丁胺核酸转酶 (NNT) 在皮肤颜色的作用.
- 探索NNT作为皮肤色素障碍的治疗点.
主要方法:
- 准NNT酶以诱导细胞氧化转化.
- 评估黑色素成熟度和素水平.
- 在人体皮肤上局部应用小分子NNT抑制剂.
- 在小鼠和斑马鱼中分析NNT功能.
- 对NNT多态的人类群体的基因组分析.
主要成果:
- 向NNT会改变细胞的氧化还原作用,影响铁酶的降解和黑色素体的成熟.
- 在人类皮肤中,NNT抑制导致皮肤变黑,在小鼠中增加色素.
- 基因修饰NNT影响斑马鱼的黑色细胞色素.
- NNT单核酸多态与人体皮肤颜色,晒和防晒行为有关.
- 皮肤NNT水平的降低与炎症后的多发色素和色素相关.
结论:
- 通过NNT调节的皮肤颜色的新型,UV和MITF独立的机制已被确定.
- 通过氧化还原依赖途径控制欧美氨酸的产生,NNT起着至关重要的作用.
- 用局部药物向NNT提供了治疗皮肤色素的医疗和化品应用的潜力.
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