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转移的微生物组组成决定了治疗HIV感染的免疫结果

Krystelle Nganou-Makamdop¹, Aarthi Talla², Ashish Arunkumar Sharma³

¹Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Institute of Clinical and Molecular Virology, University Hospital Erlangen, 91054 Erlangen, Germany.

|July 8, 2021

概括

微生物组的变化会影响艾滋病毒的恢复. 在开始联合抗逆转录病毒治疗 (cART) 后,特定的细菌转移,如增加的Serratia,促进CD4 T细胞的恢复和免疫平衡.

科学领域:

免疫学
微生物学
病毒学

背景情况:

微生物组在艾滋病毒疾病中的作用已被认可,但将微生物变化与疾病进展联系在一起的机制尚不清楚.
抗逆转录病毒治疗 (ART) 影响肠道微生物群,但其对免疫恢复的影响需要进一步阐明.

研究的目的:

调查HIV联合抗逆转录病毒疗法 (cART) 中微生物转移的动态变化及其对免疫恢复的影响.
确定影响CD4T细胞恢复和全身免疫恒温的特定微生物通路.

主要方法:

在开始使用cART的HIV患者中,对微生物成分和宿主免疫反应进行纵向分析.
系统生物学方法识别与免疫变化相关的微生物属比.
对多个艾滋病毒群体的分析,以概括发现.

主要成果:

在CART开始后,观察到转移的微生物产品的快速,动态变化.
一个涉及塞拉蒂亚细菌属丰度比率的独特途径与免疫恢复相关.
高的Serratia丰度与增加的CD4T细胞,促炎细胞因子和粘膜愈合有关.
随后的Serratia和炎症降低促进了T细胞平衡和Th1/Th2签名的恢复.

结论:

转移的微生物物种组成的变化显著影响治疗HIV感染的全身炎症和CD4T细胞恢复.
特定细菌属的比率,如Serratia,在HIV治疗期间对调节免疫反应起着至关重要的作用.
结果表明,一种普遍的原理将微生物转移动态与HIV免疫复合联系起来.

关键词:

艾滋病毒抗逆转录病毒治疗炎症发生微生物组系统生物学

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