Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

11.8K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
11.8K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

1.3K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.3K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

77.4K
Overview
77.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Differential stem-like potential of naïve and memory CD8 T cells after chronic infection.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

New insights into progenitor exhausted T cell populations.

Nature reviews. Immunology·2026
Same author

Simultaneous TCR and IL-2 agonism selectively enhances epitope-specific CD8 T-cell responses during chronic viral infection.

Journal of virology·2026
Same author

Neuroprotective Phytochemicals Targeting Amyloid and Tau Pathologies.

Current topics in medicinal chemistry·2026
Same author

Coadministration of rapamycin with a DNA/MVA SIV vaccine improves memory CD8+ T cell response.

JCI insight·2026
Same author

CD8+ T cells and Humoral Immunity Influence the Development of Antibody-Dependent Enhancement: Implications for Vaccine Design.

bioRxiv : the preprint server for biology·2026

相关实验视频

Updated: Oct 29, 2025

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.5K

人类CD28缺乏的免疫学教训

Andreas Wieland1, Rafi Ahmed1

  • 1Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA; Department of Microbiology & Immunology, Emory University School of Medicine, Atlanta, GA, USA.

Cell
|July 9, 2021
PubMed
概括

一种导致T细胞分子CD28缺乏的突变导致三名家族成员的严重病毒感染和不良疫苗反应. 这突出了CD28

科学领域:

  • 免疫学和分子生物学
  • 人类遗传与传染病

背景情况:

  • 对于适应性免疫来说,T细胞的共同刺激至关重要.
  • CD28是一个关键的T细胞共刺激分子,对免疫反应至关重要.
  • 免疫分子的遗传缺陷可能导致严重的临床表现.

研究的目的:

  • 研究导致CD28缺陷的突变的临床和免疫后果.
  • 分析 CD28 缺乏症患者对特定病毒感染的易感性.
  • 评估CD28缺乏对疫苗疗效的影响.

主要方法:

  • 对三名受影响家庭成员的临床案例研究.
  • 分子基因分析以确定突变.
  • 免疫学测试以评估T细胞功能和病毒载荷.

主要成果:

  • 发现了一种导致T细胞共刺激分子CD28缺乏的突变.
  • 患者表现出严重的临床症状,包括感染人类乳头瘤病毒-2和-4.
  • 检测出埃普斯坦- 巴尔病毒和细胞巨病毒的高水平,以及对疫苗接种的反应不佳.

结论:

  • CD28 缺乏严重损害免疫系统,导致易受机会性病毒感染.

更多相关视频

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
10:13

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Published on: May 6, 2019

9.2K
Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
14:23

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

24.4K

相关实验视频

Last Updated: Oct 29, 2025

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.5K
Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
10:13

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Published on: May 6, 2019

9.2K
Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
14:23

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

24.4K
  • 这些发现强调了CD28在维持免疫平衡和有效的疫苗反应中的关键作用.
  • 这项研究为CD28相关免疫缺陷的发病提供了关键的见解.