肠道微生物群的遗传性几乎是普遍的,但在环境上是偶然的
Laura Grieneisen1, Mauna Dasari2, Trevor J Gould3
1Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA. lgrienei@umn.edu blekhman@umn.edu earchie@nd.edu jenny.tung@duke.edu.
概括
主体基因对肠道微生物有很大影响,97%的特征是野生的遗传特征. 这种对肠道微生物群的遗传影响因季节,饮食和宿主年龄而异.
科学领域:
- 微生物学
- 遗传学
- 生态学
背景情况:
- 在亲属中观察到肠道微生物组的相似性,但宿主遗传与共享环境的贡献仍然存在争议.
- 了解肠道微生物组合的驱动因素对于宿主健康和进化至关重要.
研究的目的:
- 在野生群体中研究肠道微生物体表型的遗传性.
- 确定宿主基因在多大程度上影响了肠道微生物群.
主要方法:
- 分析了14年来585只野生的16234个肠道微生物组.
- 使用统计模型来控制饮食,年龄和社会生态因素.
- 各种微生物体表型的量化遗传性.
主要成果:
- 几乎所有 (97%) 的微生物群表型都表现出显著的遗传性.
- 遗传能力通常较低,但在干旱季节增加,饮食多样性较低,老.
- 纵向数据和大样本大小对于准确的遗传性估计至关重要.
结论:
- 宿主基因在塑造肠道微生物群中起着近乎普遍的作用.
- 微生物组的遗传性是动态的,受环境和宿主因素的影响.
- 这些发现表明自然选择可能会影响宿主微生物组的特征.
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