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Updated: Oct 29, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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探索β2AR-Gs复合物的激活过程

Chen Bai1,2, Junlin Wang2, Dibyendu Mondal1

  • 1Department of Chemistry, University of Southern California, Los Angeles, California 90089-1062, United States.

Journal of the American Chemical Society
|July 13, 2021
PubMed
概括

G蛋白结合受体 (GPCR) 对细胞信号传递和药物开发至关重要. 这项研究表明,当结合腔半开时,从Gs蛋白中释放酸 (GDP),这是GPCR激活的关键步骤.

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