慢性稳定性心脏病的发展和国际观察分析:多国CLARIFY研究
Jules Mesnier1,2, Gregory Ducrocq1,2,3,4, Nicolas Danchin4,5
1Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, France (J.M., G.D., P.G.S.).
Circulation
|July 15, 2021
概括
稳定的冠状动脉疾病患者患有胸痛通常会在保守的治疗下症状消失. 这种方法预测了类似于从未患上心痛的结果,
科学领域:
- 心脏病学
- 临床医学
- 流行病学
背景情况:
- 在稳定的冠状动脉疾病 (CAD) 患者中,心痛很常见.
- 关于心痛的流行,演变和现代治疗结果的数据有限.
研究的目的:
- 在稳定的CAD中调查心痛的自然史.
- 分析心痛状态对长期心血管结果的影响.
主要方法:
- 分析了来自CLARIFY注册表的32,691名患者.
- 在没有新的心肌血管或心肌梗塞的患者中,每年评估胸痛状况.
- 在5年的结果中对1年的心痛变化进行多变量分析.
主要成果:
- 在没有重新血管化的患者中,心痛在1年内消失.
- 在不需要改变药物治疗的情况下,患者常常能恢复 (84. 4%).
- 持续性或新的心痛增加了心血管死亡或心肌梗塞的风险 (调整后的HR为1. 32和1. 37).
结论:
- 大多数患有心血管炎的稳定患者会出现症状的消失.
- 保守的治疗导致胸痛的解决与有利的结果有关.
- 强调保守治疗对稳定性心脏病的常规再血管化的价值.
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