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Humans engage in aggression when they seek to cause harm or pain to another person. Aggression takes two forms depending on one’s motives: hostile or instrumental. Hostile aggression is motivated by feelings of anger with intent to cause pain; a fight in a bar with a stranger is an example of hostile aggression. In contrast, instrumental aggression is motivated by achieving a goal and does not necessarily involve intent to cause pain (Berkowitz, 1993); a contract killer who murders for...
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The optimal arousal theory suggests that performance is maximized when an individual experiences a moderate level of arousal. This theory is closely tied to the Yerkes-Dodson law, which illustrates an inverted U-shaped relationship between arousal and performance. The law, formulated by psychologists Robert Yerkes and John Dodson, implies an ideal arousal level for optimal performance, and deviations from this level can lead to declines in effectiveness.
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Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses
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在防御行为期间的动态前额群编码

Daniel Jercog1,2, Nanci Winke3,4, Kibong Sung3,4,5

  • 1Univ. Bordeaux, Neurocentre Magendie, U1215, Bordeaux, France. daniel.jercog@inserm.fr.

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概括
此摘要是机器生成的。

背中前额皮层 (dmPFC) 动态地将威胁线索与防御行动联系起来. 在行动开始前的短暂dmPFC活动预测了成功的避开行为,这对生存至关重要.

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科学领域:

  • 神经科学
  • 行为神经科学

背景情况:

  • 威胁检测和适应性行为反应对于生存至关重要.
  • 背中前额皮质 (dmPFC) 在调节与威胁相关的行为方面发挥着关键作用.
  • 连接威胁感知到前线网络中的防御行动的确切机制尚不清楚.

研究的目的:

  • 研究如何在dmPFC神经活动中动态编码威胁预测刺激和防御行为.
  • 阐明dmPFC群体动态在适应性防御反应的启动和选择中的作用.

主要方法:

  • 在小鼠中进行细胞外记录以捕捉神经活动.
  • 神经元解码以解释人口层面的神经信号.
  • 药物学和光遗传学操作以探测dmPFC的功能.
  • 避免威胁的行为分析.

主要成果:

  • 刺激开始时的dmPFC群体活动编码了持续的威胁表现,但没有预测行动结果.
  • 在行动启动之前的过渡性dmPFC群体活动可靠地区分避免的试验和未避免的试验.
  • 对dmPFC的光遗传抑制以时间依赖的方式损害了自适应防御反应的选择.

结论:

  • 适应性防御性行为选择依赖于前额网络中的动态过程.
  • 该dmPFC集成了威胁信息和行动启动信号,以指导适应性反应.
  • 在dmPFC中神经动态对于将威胁线索与适当的行为输出至关重要.