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一种强大的抗生素候选物伊博克萨米的实用克尺度合成

Jeremy D Mason1, Daniel W Terwilliger1, Aditya R Pote1

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States.

Journal of the American Chemical Society
|July 15, 2021
PubMed
概括

获得了抗生素候选物iboxamycin的克尺度合成. 这种新途径为感染模型的体内研究提供了足够的数量.

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Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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