机器学习的Fe-催化Fischer-Tropsch合成中的CO激活活体
Qian-Yu Liu1, Cheng Shang1, Zhi-Pan Liu1
1Collaborative Innovation Center of Chemistry for Energy Material, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Key Laboratory of Computational Physical Science, Department of Chemistry, Fudan University, Shanghai 200433, China.
Journal of the American Chemical Society
|July 19, 2021
概括
机器学习模拟在费舍尔-托普施合成 (FTS) 过程中确定了碳氧化物 (CO) 激活铁碳化物 (FeC) 催化剂的活性位点. 这项研究揭示了FeC表面和碳空缺对于烯酸生产至关重要,进步了催化剂设计.
科学领域:
- 不同质的催化
- 材料科学
- 计算化学
背景情况:
- 铁碳化物 (FeC) 对于工业费舍尔-托普施合成 (FTS) 至关重要,从CO和H2中产生长链碳化合物.
- 化碳的FeC催化剂的确切活性点仍然是一个长期存在的未解决的争议.
- 了解FeC结构和CO化机制对于开发高效的催化剂至关重要.
研究的目的:
- 在FTS条件下使用计算方法来确定碳酸铁催化剂的活性位点.
- 在没有先前的实验假设的情况下探索大量的FeC批量和表面结构.
- 为设计改进的FTS催化剂建立结构-活性相关性.
主要方法:
- 使用机器学习模拟来探索数百万个FeC批量和表面结构候选者.
- 构建了散体相的热力学凸体船体,以确定稳定的FeC组成.
- 评估的表面能量,CO和H吸附,以及CO激活的反应途径.
主要成果:
- 在FTS条件下确定Fe5C2,Fe7C3和Fe2C为稳定的散装相.
- 确定只有三个表面能量低的FeC表面 (χ-Fe5C2 (((510), χ-Fe5C2 (((111) 和 η-Fe2C (((111)) 可以吸附.
- 发现CO激活发生在动态形成的表面碳空隙中通过直接解离.
结论:
- 机器学习模拟成功地确定了碳化铁催化剂上的CO激活位点.
- 特定的FeC表面和碳空缺对于FTS中的CO化机制至关重要.
- 这种原子层面的理解为设计更有效的费舍尔-托普施催化剂提供了基础.
相关概念视频
Introduction to Mechanisms of Enzyme Catalysis
9.3K
For many years, scientists thought that enzyme-substrate binding took place in a simple "lock-and-key" fashion. This model stated that the enzyme and substrate fit together perfectly in one instantaneous step. However, current research supports a more refined view scientists call induced fit. The induced-fit model expands upon the lock-and-key model by describing a more dynamic interaction between enzyme and substrate. As the enzyme and substrate come together, their interaction causes...
9.3K
Induced-fit Model
85.7K
Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon.
Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical...
Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical...
85.7K
Ligand Binding and Linkage
5.1K
Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked. In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
5.1K
Allosteric Proteins-ATCase
6.1K
Binding sites linkages can regulate a protein's function. For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis...
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis...
6.1K
Predicting Reaction Outcomes
8.9K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
8.9K
Coupled Reactions
9.2K
Cellular processes such as building and breaking down complex molecules occur through stepwise chemical reactions. Some of these chemical reactions are spontaneous and release energy, whereas others require energy to proceed. Cells often couple the energy-releasing reaction with the energy-requiring one to carry out important cell functions.
Energy in adenosine triphosphate or ATP molecules is easily accessible to do work. ATP powers the majority of energy-requiring cellular reactions....
Energy in adenosine triphosphate or ATP molecules is easily accessible to do work. ATP powers the majority of energy-requiring cellular reactions....
9.2K


