不活性基的非对称化
Xu-Teng Liu1, Xue-Yu Han1, Yue Wu1
1Department of Chemistry, University of Science and Technology of China, Hefei 230026, People's Republic of China.
Journal of the American Chemical Society
|July 20, 2021
概括
一种新的催化方法有效地从易于获得的材料中合成了性三级. 这一突破为催化和材料科学提供了更安全,更多用途的P(III) 化合物.
科学领域:
- 有机化学
- 催化剂
- 材料科学
背景情况:
- 在非对称催化,材料科学和制药化学中,体三级素是关键的组成部分.
- 由于控制立体化学和处理对空气敏感的中间体的困难,合成P-立体三级素是一个重大挑战.
研究的目的:
- 为合成P类固醇三级素开发一种实用的区域和酶选择性方法.
- 克服与有毒和对空气敏感的素前体相关的局限性.
主要方法:
- 使用廉价且丰富的类的催化化反应.
- 在实验室稳定的二次氧化物中生成二次.
主要成果:
- 证明了前所未有的基质范围和功能组兼容性.
- 在电子和结构上成功合成了多种P(III) 化合物.
- 产品很容易转化为双联体,有机催化剂和过渡金属复合物的前体.
结论:
- 开发的方法提供了一种有效和安全的途径,以获得有价值的合素化合物.
- 这种方法扩大了P-类固醇因在催化及其他领域的各种应用的可用性.
- 合成的化合物作为先进的功能分子和材料的多功能前体.
相关概念视频
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Like alkenes, alkynes can be reduced to alkanes in the presence of transition metal catalysts such as Pt, Pd, or Ni. The reaction involves two sequential syn additions of hydrogen via a cis-alkene intermediate.
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02:47Alkynes to Aldehydes and Ketones: Hydroboration-Oxidation
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One of the convenient methods for the preparation of aldehydes and ketones is via hydration of alkynes. Hydroboration-oxidation of alkynes is an indirect hydration reaction in which an alkyne is treated with borane followed by oxidation with alkaline peroxide to form an enol that rapidly converts into an aldehyde or a ketone. Terminal alkynes form aldehydes, whereas internal alkynes give ketones as the final product.
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02:40Alkynes to Aldehydes and Ketones: Acid-Catalyzed Hydration
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