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马西替尼是一种广泛的冠状病毒3CL抑制剂,可以阻止SARS-CoV-2的复制

Nir Drayman1, Jennifer K DeMarco2, Krysten A Jones3,4

  • 1Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA. tays@uchicago.edu nirdra@uchicago.edu.

Science (New York, N.Y.)
|July 21, 2021
PubMed
概括

马西替尼通过向3CLpro酶有效抑制SARS-CoV-2的复制. 这种候选药物在细胞培养和动物模型中表现出显著的抗病毒活性,包括针对主要变异.

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