肠道细胞因子通过细胞质的代谢重编程来调节嗅觉
Xiaoyu Tracy Cai1,2,3, Hongjie Li4,5,6, Martin Borch Jensen2,7
1Immunology Discovery, Genentech, Inc., South San Francisco, CA, USA.
Nature
|July 22, 2021
概括
果的肠道感染重新编程脑细胞, 改变嗅觉, 促进生存. 这种与炎症相关的效应在老中变得永久, 损害了它们的嗅觉.
科学领域:
- 神经科学
- 免疫学
- 遗传学
背景情况:
- 感染引起的厌恶对于宿主生存至关重要.
- 之前的研究将感官感知与对抗微生物的回避行为联系起来.
- 肠道感染对感官感知的直接影响尚不清楚.
研究的目的:
- 研究肠道感染如何调节感官感知.
- 了解感染引起的厌恶的机制.
- 探索质细胞在调解这些变化的作用.
主要方法:
- 作为一个模型生物的Drosophila melanogaster.
- 基因表达和信号通路的分析 (JAK-STAT).
- 对嗅觉歧视和行为回避的评估.
主要成果:
- 肠道病原体感染会重新编程天线叶中的质细胞.
- 感染激活了JAK-STAT信号,改变了细胞质代谢和神经元-细胞质合.
- 这导致了调节的嗅觉区分,增加了避免受污染的食物,增加了的生存率.
- 年龄相关的肠道炎症导致老持续的质重编程和嗅觉衰退.
结论:
- 由肠道产生的细胞因子诱导适应性质代谢重编程,改变感官感知.
- 这种机制解释了嗅觉系统的长期变化,
- 质代谢重编程是疾病行为和与年龄相关的感官衰退的关键因素.
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