以ACE2受体改性藻类为基础的微机器人用于废水中清除SARS-CoV-2
Fangyu Zhang1, Zhengxing Li1, Lu Yin1
1Department of NanoEngineering and Chemical Engineering Program, University of California San Diego, La Jolla, California 92093, United States.
Journal of the American Chemical Society
|July 22, 2021
概括
科学家使用藻类开发了一种新型微机器人,用于从水中捕获和清除SARS-CoV-2 (导致COVID-19的病毒). 这种生物混合系统有效地从废水中去除病毒颗粒和尖端蛋白, 为净化水提供了一种新的方法.
科学领域:
- 环境科学
- 生物技术
- 纳米技术
背景情况:
- SARS-CoV-2 可以在废水中持续存在,造成由水传播的风险.
- 有效的制策略对于控制病毒传播至关重要.
研究的目的:
- 开发一个活跃的生物混合微机器人系统,以有效捕获和从水环境中去除SARS-CoV-2.
- 研究功能化微藻的自我推进能力和病毒去除效果.
主要方法:
- 使用点击化学方法对SARS-CoV-2尖端蛋白进行功能化,使用血管激素转化酶2 (ACE2) 受体.
- 由此产生的ACE2藻微机器人在各种水类中表现出无需外部燃料的自我推进能力.
- 量化了病毒尖端蛋白和伪病毒的去除效率.
主要成果:
- ACE2藻微机器人表现出快速的自我推进 (> 100μm/s) 和持续的活动 (> 24小时).
- 微机器人实现了95%的SARS-CoV-2尖端蛋白和89%的伪病毒的去除.
- 性能明显超过对照组 (静态ACE2藻类和裸藻类).
结论:
- 基于功能化的藻类的生物混合微机器人显示出从废水中去除病毒的巨大潜力.
- 这项技术为净化水和减轻环境威胁提供了可持续且无燃料的方法.
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