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Updated: May 5, 2026

Novel Passive Clearing Methods for the Rapid Production of Optical Transparency in Whole CNS Tissue
06:14

Novel Passive Clearing Methods for the Rapid Production of Optical Transparency in Whole CNS Tissue

Published on: May 8, 2018

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在MAPT突变大脑器官中,ELAVL4,拼接和质功能障碍是神经元损失的先例

Kathryn R Bowles1, M Catarina Silva2, Kristen Whitney3

  • 1Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Departments of Genetics and Genomic Sciences, Neuroscience, and Neurology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.

Cell
|July 27, 2021
PubMed
概括

使用干细胞模型的前性痴呆症 (FTD) 研究显示,早期的积和胺路径变化导致神经元丧失. 一种PIKFYVE抑制剂在突变神经元中拯救了谷氨酸毒性.

关键词:
其他国家美国自食症前性痴呆症葡萄糖性神经元有机物接合方式突触信号传递病症

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Published on: March 11, 2020

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Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis08:59

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Published on: July 16, 2021

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Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
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