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Updated: Oct 26, 2025

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BARD1 读取 H2A 素 15 无化到直接同源重组

Jordan R Becker1,2, Gillian Clifford3, Clara Bonnet1,2

  • 1Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

Nature
|July 29, 2021
PubMed
概括

BRCA1-BARD1复合体通过一种新型动机将BRCA1招募到DNA双链断裂中,该动机涉及组织蛋白修饰. 这种相互作用对同类重组修复至关重要,并对抗53BP1通路.

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