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In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
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Published on: July 25, 2019

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BRCA1-BARD1核细胞识别和无处不在的机制

Qi Hu1, Maria Victoria Botuyan1, Debiao Zhao1

  • 1Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.

Nature
|July 29, 2021
PubMed
概括

该BRCA1-BARD1复合体通过基因组修饰与DNA双链断裂结合,从而招募全域结酶. 这种机制解释了它在DNA修复和癌症发展中的作用.

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