相关实验视频

Updated: Oct 26, 2025

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

Published on: May 4, 2021

甲状腺层淋巴蛋白通过脂质过分分泌诱导脂肪损失

Ruth Choa¹, Junichiro Tohyama¹, Shogo Wada²

¹Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Science (New York, N.Y.)

|July 30, 2021

概括

胸膜淋巴细胞 (TSLP) 和T细胞通过增加皮肤的皮脂产量来促进脂肪的流失. 这种以免疫为媒介的机制为治疗肥胖和相关代谢疾病提供了新的途径.

科学领域:

免疫学
代谢过程
皮肤病学

背景情况:

免疫系统在调节全身新陈代谢中的作用是一个新兴的研究领域.
肥胖和非酒精性脂肪肝炎 (NASH) 是具有复杂代谢基础的全球重大健康挑战.

研究的目的:

研究胸膜淋巴细胞蛋白 (TSLP) 在调节脂肪组织和全身代谢中的作用.
阐明TSLP影响脂肪减轻和代谢健康的机制.

主要方法:

使用小鼠模型和人类皮肤样本.
研究TSLP对T细胞和白脂肪组织的影响.
分析了与脂质和抗菌相关的脂质产生,脂质损失和基因表达.

主要成果:

通过TSLP刺激的T细胞诱导选择性白脂肪损失,独立于食物摄入量或能量消耗的变化.
脂肪流失是通过皮肤过度流失的脂质.
TSLP和T细胞调节脂质释放和相关的抗菌的表达.
人体皮肤显示TSLP表达与皮脂相关基因表达之间存在直接相关性.

结论:

通过TSLP和T细胞调节的脂质过分分泌的新机制已被确定.
适应性免疫通过皮脂分泌起到皮肤屏障的作用.
这一发现为肥胖,新陈代谢功能障碍和NASH开辟了新的治疗可能性.

更多相关视频

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Published on: May 19, 2023

Isolation of Adipose Tissue Immune Cells

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

相关概念视频

Hypodermis

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...