通过控制基酸盐的协调来制备基于金属有机框架的药物载体:提高体稳定性和再分散性
Xu Chen1, Yunhui Zhuang1, Nakul Rampal1
1The Adsorption & Advanced Materials Laboratory (A2ML), Department of Chemical Engineering & Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, United Kingdom.
Journal of the American Chemical Society
|August 6, 2021
概括
这项研究引入了一种用于药物输送的稳定,可再分散的金属有机框架纳米粒子 (nanoMOF) 的新方法. 通过PEGylation和冷化,可以克服存储和聚合的问题,从而提高其临床潜力.
科学领域:
- 材料科学
- 纳米技术
- 生物医学工程
背景情况:
- 金属有机框架纳米颗粒 (纳米MOF) 在生物医学应用中具有前景.
- 目前的限制包括复杂的合成,有毒的试剂和溶液的不良保质期.
- 这些障碍阻碍了纳米MOF的临床转化.
研究的目的:
- 开发一种用于储存纳米MOF的简单和通用配方方法.
- 提高纳米MOF的稳定性和再分散性,用于生物医学.
- 研究PEGylation对纳米MOF特性和药物输送的影响.
主要方法:
- 纳米MOF的合成后修饰用酸功能化甲聚乙烯甘醇 (mPEG-PO3).
- 软化以创建稳定,可再分散的固体纳米MOF材料.
- PEGylated纳米MOF的特征,包括水力动力直径,体稳定性和药物释放动力学.
- 细胞内稳定性,药物释放和细胞毒性的体外评估.
主要成果:
- 基化纳米MOF显示稳定的水力动力直径和更好的体稳定性.
- 在水中完全重新分散,克服聚合问题.
- 观察到增强的细胞内稳定性和延迟的药物释放动力学.
- 与裸体纳米MOF相比,PEGylated纳米MOF的细胞毒性较低.
结论:
- 使用mPEG-PO3的轻易PEGylation方法产生稳定,可再分散的纳米MOF.
- 这种配方策略显著改善了用于生物医学应用的纳米MOF存储和处理.
- 开发的PEGylated纳米MOF显示为药物输送的先进纳米载体的潜力.
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