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人类TBK1缺乏导致由TNF诱导的细胞死亡引起的自身炎症

Justin Taft1, Michael Markson1, Diana Legarda2

  • 1Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

Cell
|August 7, 2021
PubMed
概括

在人体中,TANK结合激酶1 (TBK1) 的功能丧失突变引起自身炎症,而不是严重的感染. 通过减少TNF诱导的细胞死亡,抗TNF治疗改善了患者的状况.

关键词:
其他国家国际资金基金一个RIPKTBK1 缺乏症在TNFα自燃性炎症干扰素I型病毒易感性

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