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Updated: Oct 25, 2025

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches
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使用腺病毒载体和mRNACOVID-19疫苗 (Com-COV) 进行异质与同质原始增强计划的安全性和免疫性:单盲,随机,非劣势试验

Xinxue Liu1, Robert H Shaw2, Arabella S V Stuart2

  • 1Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.

Lancet (London, England)
|August 9, 2021
PubMed
概括

使用AstraZeneca (ChAd) 和Pfizer-BioNTech (BNT) 疫苗进行异质性COVID-19疫苗接种显示出有前景. 虽然ChAd/BNT达到非劣势,但BNT/ChAd没有,尽管两者都诱导了比单独ChAd/ChAd更高的抗体水平.

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Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

Bioavailability Study Design: Single Versus Multiple Dose Studies

Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
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Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
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Bioequivalence studies: Biowaivers01:13

Bioequivalence studies: Biowaivers

Body:In certain scenarios, in vitro dissolution tests can replace in vivo bioequivalence studies. This is particularly true when a drug product, though available in varying strengths, maintains proportional similarity in its active and inactive ingredients. In such cases, the need for in vivo bioequivalence studies for lower strength variants may be waived, provided dissolution tests and in vivo studies on the highest strength yield satisfactory results.Bioequivalence can be indicated through...
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