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用蛋白模仿二氨酸控制原始结构之外的两聚合物折叠

Jacqueline L Warren¹, Peter A Dykeman-Bermingham¹, Abigail S Knight¹

¹Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

Journal of the American Chemical Society

|August 10, 2021

概括

合成聚合物可以通过结合非共价相互作用来模仿蛋白质功能. 这项研究表明,特定的单体设计,如二烯胺,如何在合成聚合物中形成有序的,类似蛋白质的结构.

科学领域:

聚合物化学
生物材料科学
超分子化学

背景情况:

自然生物聚合物由于复杂的非对应相互作用而表现出复杂的功能.
目前的合成聚合物策略在复制这些复杂的相互作用方面是有限的.
开发具有类似蛋白质功能的合成聚合物需要对非共价相互作用进行精确控制.

研究的目的:

探索非共价相互作用对合成聚合物的有序组装的影响.
研究生物启发的二氨胺 (FF) 单体用于制造类似蛋白质的结构.
建立合成聚合物中更高阶结构的设计原则.

主要方法:

使用FF单体合成两性共聚物.
在水性环境中聚合物组合的分析.
通过循环二重化和硫黄素T光来描述局部和全球结构.
对单体成分进行系统变化,以研究非共价相互作用效应.

主要成果:

两性共聚物形成单链组合,具有类似β片的局部结构.
全球集体的崩主要是由疏水力驱动的.
水素结合和芳香相互作用稳定了当地的β-叶状结构.
修改芳香残留物的放置 (例如,氨酸-氨酸烯胺) 诱导了类似的结构,但稳定性降低.
提供键的单体破坏了FF组件的内部结构.

结论:

在合成聚合物中,可以轻松结合多种蛋白模拟特征.
恐水力驱动全球崩, 而结和芳香相互作用稳定了当地结构.
单体设计,包括芳香残留物定位和水友性相互作用,对合成聚合物中更高阶结构的形成和稳定性产生关键影响.

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