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Updated: Oct 22, 2025

Small RNA Transfection in Primary Human Th17 Cells by Next Generation Electroporation
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免疫刺激RNA RN7SL1使CAR-T细胞能够增强自主和内生免疫功能

Lexus R Johnson1, Daniel Y Lee2, Jacqueline S Eacret2

  • 1Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Mark Foundation Center for Immunotherapy, Immune Signaling, and Radiation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Cell
|August 31, 2021
PubMed
概括

改造的CAR-T细胞提供RN7SL1RNA以增强抗瘤免疫力并克服抗原损失. 这种策略增强T细胞功能和内生免疫反应,改善固体瘤的排斥.

关键词:
CAR-T细胞,RN7SL1,7SL,模式识别受体,RIG-I,MDA5,干扰素,细胞外囊

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