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相关概念视频

Proteomics01:33

Proteomics

8.6K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Protein Networks02:26

Protein Networks

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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相关实验视频

Updated: Oct 21, 2025

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

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快照:临床蛋白质组学

Yi Zhu1, Ruedi Aebersold2, Matthias Mann3

  • 1Westlake Laboratory of Life Sciences and Biomedicine, Westlake University, Hangzhou, China.

Cell
|September 3, 2021
PubMed
概括
此摘要是机器生成的。

临床样本的定量蛋白质组分析提供了对健康和疾病的关键见解. 本概述涵盖了分析蛋白质组成的常见和新兴的质谱 (MS) 工作流程.

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Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples
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A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease
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A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease

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Last Updated: Oct 21, 2025

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples
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科学领域:

  • 生物化学
  • 分析化学
  • 临床蛋白质学

背景情况:

  • 临床样本的定量蛋白质组分析对于理解生理和病理状态至关重要.
  • 现有多种方法,需要对当前的方法进行总结.

研究的目的:

  • 为量化蛋白质组分析提供基于质谱 (MS) 的常见和新兴工作流程的概述.
  • 突出蛋白质组分析在临床环境中的重要性.

主要方法:

  • 基于质谱 (MS) 的工作流程是主要重点.
  • 讨论包括既有和新的MS技术.

主要成果:

  • 摘要显示了基于MS的工作流程的总结.
  • 由于概述性质和空间限制,具体结果没有详细说明.

结论:

  • 使用MS的定量蛋白质组分析是临床研究的宝贵工具.
  • 这一领域随着新兴国家和地区的方法不断发展.