在英国的ChAdOx1 nCoV-19第二剂或第三剂后的反应性和免疫性:两项随机对照试验的副研究 (COV001和COV002)
Amy Flaxman1, Natalie G Marchevsky2, Daniel Jenkin1
1Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Lancet (London, England)
|September 4, 2021
概括
延长COVID-19疫苗 (ChAdOx1 nCoV-19) 剂量之间的间隔可以提高抗体反应. 第三剂疫苗进一步增强了抗体和T细胞免疫力,显示出更好的保护.
科学领域:
- * 免疫学和疫苗学
- * 传染病流行病学
- * 临床试验和翻译研究
背景情况:
- * 全球COVID-19疫苗供应短缺需要评估延长剂量间隔.
- * 全球正在考虑不同的疫苗接种策略,包括延迟第二剂和第三剂强剂.
- * 评估ChAdOx1 nCoV-19 (AZD1222) 免疫性对于优化疫苗疗效至关重要.
研究的目的:
- * 评估一次剂量ChAdOx1 nCoV-19后免疫力的持续性.
- * 在第一次和第二次ChAdOx1 nCoV-19剂量之间延长间隔 (44 - 45周) 后评估免疫性.
- * 用于确定第三次ChAdOx1 nCoV-19剂量的免疫反应.
主要方法:
- * 从第1阶段 (COV001) 和第2阶段 (COV002) ChAdOx1 nCoV-19试验中对18-55岁的志愿者进行子研究.
- * 对延迟第二剂 (44 - 45周) 和第三剂 (28 - 38周后) 的反应性和免疫性数据的分析.
- * 与接受标准两剂治疗方案的参与者和接受单剂治疗的44至45周的参与者的数据进行比较.
主要成果:
- * 在一次ChAdOx1 nCoV-19剂量后,抗体标量持续高于基线的44 - 45周.
- 与较短的间隔 (8 - 12周或15 - 25周) 相比,剂量间隔较长 (44 - 45周) 导致抗体标位较高.
- * 第三剂量显著增加了抗体标位和T细胞反应,反应性低于第一剂量.
结论:
- * 延长第二次ChAdOx1 nCoV-19剂量间隔可以提高抗体反应.
- * 第三次ChAdOx1 nCoV-19剂量有效提高了抗体水平和T细胞反应.
- * 结果支持灵活的ChAdOx1 nCoV-19疫苗接种计划以优化免疫保护.
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