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针对COVID-19的三价子单位候选疫苗及其输送装置

Oscar A Ortega-Rivera, Matthew D Shin, Angela Chen

¹Institute for Antiviral Research, Utah State University, Logan, Utah 84322, United States.

Journal of the American Chemical Society

|September 7, 2021

概括

这项研究介绍了一种针对COVID-19的新型纳米技术疫苗平台,提供热稳定性和自给药选择. 该平台使用保存的病毒表位来广泛保护变种,提高疫苗的可用性.

科学领域:

纳米技术
疫苗开发
病毒学

背景情况:

由于COVID-19的流行,新出现的病毒威胁需要快速开发疫苗.
目前针对SARS-CoV-2尖端蛋白的疫苗面临的挑战包括冷链要求,主要提升时间表和新出现的关注变种 (VOC).

研究的目的:

为SARS-CoV-2开发一种新型,热稳定的纳米技术疫苗平台.
识别保存的病毒表位,以广泛保护对VOCs.
创建可以自行使用的疫苗配方.

主要方法:

从SARS-CoV-2中鉴定了三种保存的中和化表位.
使用牛马赛克病毒 (CPMV) 和菌体Qβ病毒样颗粒 (VLPs) 制备候选疫苗.
开发单剂量可注射缓释聚合物植入物和微针 (MN) 贴片用于自我注射.

主要成果:

疫苗候选物显示出高热稳定性,消除了对冷链的依赖.
在小鼠中免疫接种产生高抗体标位,阻断受体结合并中和SARS-CoV-2.
配方允许单剂量或自我管理,克服后勤障碍.

结论:

一个多功能纳米技术疫苗平台为COVID-19和未来的病毒性疾病提供了稳定,可访问的解决方案.
该平台允许通过交换表位素快速适应新的病毒突变或新出现的威胁.
可以储存CPMV和QβVLP,以便快速应对公共卫生紧急情况.

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