一种CBP/p300双位抑制剂KIX是Myb的选择性和有效调节剂

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Updated: Oct 21, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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Stephen T Joy1, Madeleine J Henley1,2, Samantha N De Salle1,2

  • 1Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.

Journal of the American Chemical Society
|September 7, 2021
PubMed
概括

研究人员开发了MybLL-tide,这是一种强大的双位体抑制剂,针对Myb-CBP/ p300 KIX相互作用,对急性髓性白血病 (AML) 和其他癌症至关重要.

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