EDS1-PAD4-ADR1节点介导阿拉比多普西斯模式触发的免疫力
Rory N Pruitt1, Federica Locci2, Friederike Wanke3
1Department of Plant Biochemistry, Centre of Plant Molecular Biology (ZMBP), University of Tübingen, Tübingen, Germany.
Nature
|September 9, 2021
概括
植物使用富含白的重复免疫受体 (LRR) 来防御病原体. 这项研究揭示了Arabidopsis中模式触发免疫 (PTI) 和效应触发免疫 (ETI) 信号通路的融合点.
科学领域:
- 植物免疫力
- 分子植物微生物相互作用
- 信号传输
背景情况:
- 植物利用细胞表面和细胞内丰富的重复性免疫受体 (LRR) 来检测病原体.
- 模式触发免疫力 (PTI) 和效应器触发免疫力 (ETI) 始于不同的细胞区,但在相似的基因表达模式上趋同.
研究的目的:
- 调查PTI和ETI途径在Arabidopsis中的融合的分子机制.
- 确定PTI和ETI之间共享的关键信号组件.
主要方法:
- 研究了EDS1,PAD4和ADR1在RLP23触发的PTI中的作用.
- 利用遗传和分子方法研究蛋白质相互作用和信号复合体的形成.
- 分析了Arabidopsis加入中的LRR受体基因的进化模式.
主要成果:
- 由RLP23触发的PTI需要EDS1,PAD4和ADR1的信号能力二元,这些组件通常与ETI相关.
- 该LRR受体激酶SOBIR1作为桥梁,将RLP23与EDS1,PAD4和ADR1连接起来.
- 在血上形成涉及PTI受体和ETI传感器的超分子复合体.
- 进化分析揭示了LRR受体蛋白和LRR受体激酶基因的不同变异模式,表明它们具有特殊的作用.
结论:
- EDS1-PAD4-ADR1节点作为工厂防御信号的关键融合点.
- 表面居民 (PTI) 和细胞内 (ETI) LRR受体都激活了这个共同的节点,从而赋予病原体免疫力.
- 这一发现有助于我们更好地理解植物免疫信号通路的综合性.
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