纤维化间歇性肺病的病理学:这是关于常见的间歇性肺炎吗?
Elisabetta A Renzoni1, Venerino Poletti2, John A Mackintosh3
1Interstitial Lung Disease Unit, Royal Brompton and Harefield Clinical Group, Guy's and St Thomas' NHS Foundation Trust, London, UK; Margaret Turner Warwick Centre for Fibrosing Lung Diseases, National Heart and Lung Institute, Imperial College London, London, UK.
Lancet (London, England)
|September 9, 2021
概括
间歇性肺部疾病 (ILD) 按病因和组织病理分类,越来越多地关注渐进性纤维化. 这次审查涉及常见的间歇性肺炎是否是ILDs中这种纤维化表型的唯一驱动因素.
科学领域:
- 肺部医学
- 病理学
- 放射学
背景情况:
- 间歇性肺部疾病 (ILD) 涵盖由病因和组织病理定义的多种疾病.
- 高分辨率计算机断层扫描 (CT) 作为基因病理特征的放射替代品.
- 在ILD研究中的一个显著趋势是对渐进性纤维化表型的关注,这是由于治疗失败和抗纤维治疗的使用.
研究的目的:
- 审查ILDs的组织病理学.
- 检查ILD组织病理和渐进性纤维化之间的关系.
- 评估常见间歇性肺炎 (UIP) 在渐进性纤维化中的核心作用.
主要方法:
- 对ILD组织病理学和渐进性纤维化现有文献的综述.
- 分析常见间歇性肺炎 (UIP) 作为渐进性纤维化的原型.
- 对免疫组织化学和单细胞RNA测序等新兴技术进行讨论,以获得病原学见解.
主要成果:
- 通常的间歇性肺炎 (UIP) 是渐进性纤维化的特征性组织学模式.
- 渐进性纤维化并不仅限于UIP组织学模式.
- 先进的技术正在提高对ILD病变的理解.
结论:
- ILD 的组织病理学分类正在随着新的病原遗传见解而演变.
- 在ILD中,渐进性纤维化可能超出与通常的间歇性肺炎 (UIP) 的传统关联.
- 进一步整合先进的分子技术与组织病理学对于完善ILD分类和理解纤维化至关重要.
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