补充因子C1q在轻度脑损伤后调解睡眠损失和峰
Stephanie S Holden1,2,3,4,5, Fiorella C Grandi2,3,6,4, Oumaima Aboubakr2,4
1Neurosciences Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.
概括
轻度创伤性脑损伤 (mTBI) 导致皮质体系统的C1q慢性增加,导致神经元损失和. 阻断C1q为mTBI恢复提供了一个潜在的治疗策略.
科学领域:
- 神经科学
- 免疫学
- 病理学
背景情况:
- 创伤性脑损伤 (TBI) 严重影响皮质, 但长期残疾往往源于二次损伤.
- 泰拉木斯有着广泛的皮质体连接,是这种二次损伤的潜在地点.
- 慢性炎症和神经元功能障碍是TBI病理的主要特征.
研究的目的:
- 调查补充成分C1q在轻度TBI (mTBI) 后的二次损伤级联中的作用.
- 在mTBI后识别受影响大脑区域的C1q细胞源.
- 探索C1q作为缓解TBI相关慢性残疾的潜在治疗目标.
主要方法:
- 使用轻度TBI (mTBI) 的小鼠模型.
- 评估C1q表达,神经元损失,以及皮质层系统的炎症.
- 分析了睡眠中断和活动.
- 使用C1q阻断策略.
- 在thalamic细胞上进行单核RNA测序.
主要成果:
- 在mTBI后的皮质层系统中观察到慢性C1q升高.
- 随着神经退行和持续的炎症而增加的C1q.
- C1q上调与睡眠中断和发作相关.
- 药物阻断C1q改善了这些二次损伤结果.
- 微细胞被确定为甲状腺C1q的主要来源.
结论:
- 在mTBI的慢性阶段,C1q作为一种重要的疾病修饰剂.
- 皮质体电路,特别是产生C1q的微质体,是TBI的新治疗点.
- 向C1q可能有助于预防或治疗创伤后的长期神经缺陷.
更多相关视频
08:44Electrocorticographic Recording of Cerebral Cortex Areas Manipulated Using an Adeno-Associated Virus Targeting Cofilin in Mice
Published on: February 21, 2021
4.5K
06:23A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
Published on: September 22, 2020
5.6K
相关概念视频
Overview of Synapses
3.5K
A synapse is a specialized structure where two neurons connect, allowing them to pass an electrical or chemical signal to another neuron. It is the point of communication between neurons. The term "synapse" is derived from the Greek word "synapsis," which means "conjunction." The entire process of neural communication revolves around the synapse. When activated, a neuron releases chemicals known as neurotransmitters into the synapse. These neurotransmitters cross the synapse and bind to...
3.5K
Sleep-Wake Cycles
1.9K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.9K
Epilepsy and Seizures: Overview
370
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
370
REM Sleep Behavior Disorder
517
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
517
Seizures: Classification
691
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
691
Narcolepsy
242
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
242
