Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

8.3K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
8.3K
RNA Editing02:23

RNA Editing

9.3K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.3K
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

15.4K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
15.4K
CRISPR01:59

CRISPR

53.5K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
53.5K
What is Genetic Engineering?00:49

What is Genetic Engineering?

76.2K
Overview
76.2K
Translation01:31

Translation

16.4K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
16.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Contemporary Approaches Towards the Optimization of Embryo Implantation.

Journal of clinical medicine·2026
Same author

Protecting the health of donor-conceived offspring.

Familial cancer·2026
Same author

The National Physician Shortfall: Congress Steps Into the Breach.

The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association·2026
Same author

Stem-Cell Medicine: Unlimited Possibilities.

Journal of general internal medicine·2026
Same author

CRISPR-Cas9 therapy: expanding possibilities.

The American journal of the medical sciences·2026
Same author

Violence prevention in healthcare: An urgent priority.

The American journal of medicine·2026
Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026
Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026
Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026
Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026
Same journal

Retraction.

Science (New York, N.Y.)·2026
Same journal

Making time.

Science (New York, N.Y.)·2026
查看所有相关文章

相关实验视频

Updated: Oct 20, 2025

Author Spotlight: Advancing Techniques and Discoveries in Protein Synthesis and Assembly Through Innovative Mitochondrial Research
09:53

Author Spotlight: Advancing Techniques and Discoveries in Protein Synthesis and Assembly Through Innovative Mitochondrial Research

Published on: June 7, 2024

1.2K

线粒体疾病:替换或编辑?

Eli Y Adashi1, Donald S Rubenstein2, Jim A Mossman3

  • 1Department of Medical Science, Brown University, Providence, RI, USA.

Science (New York, N.Y.)
|September 13, 2021
PubMed
概括
此摘要是机器生成的。

线粒体替代问题表明线粒体DNA编辑的潜在作用. 这种方法可以解决与线粒体遗传有关的遗传问题.

更多相关视频

Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing
07:24

Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing

Published on: February 10, 2023

1.7K
Adeno-Associated Virus-Mediated Delivery of CRISPR for Cardiac Gene Editing in Mice
09:00

Adeno-Associated Virus-Mediated Delivery of CRISPR for Cardiac Gene Editing in Mice

Published on: August 2, 2018

8.3K

相关实验视频

Last Updated: Oct 20, 2025

Author Spotlight: Advancing Techniques and Discoveries in Protein Synthesis and Assembly Through Innovative Mitochondrial Research
09:53

Author Spotlight: Advancing Techniques and Discoveries in Protein Synthesis and Assembly Through Innovative Mitochondrial Research

Published on: June 7, 2024

1.2K
Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing
07:24

Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing

Published on: February 10, 2023

1.7K
Adeno-Associated Virus-Mediated Delivery of CRISPR for Cardiac Gene Editing in Mice
09:00

Adeno-Associated Virus-Mediated Delivery of CRISPR for Cardiac Gene Editing in Mice

Published on: August 2, 2018

8.3K

科学领域:

  • 遗传学和分子生物学
  • 细胞生物学
  • 生殖医学

背景情况:

  • 线粒体DNA (mtDNA) 是由母亲继承的.
  • 线粒体疾病通过几代人传承,影响许多细胞功能.
  • 目前的线粒体替代疗法面临着伦理和技术上的挑战.

研究的目的:

  • 探索线粒体DNA编辑作为线粒体替代方案的潜力.
  • 评估纠正卵细胞或早期胚胎中致病性mtDNA突变的可行性.
  • 讨论mtDNA编辑对预防遗传性线粒体疾病的影响.

主要方法:

  • 对mtDNA编辑技术 (例如基于CRISPR的系统) 的当前文献的审查.
  • 对mtDNA编辑效率和非目标效应的理论模型的分析.
  • 对mtDNA编辑与线粒体替代策略的比较评估.

主要成果:

  • 线粒体DNA编辑为纠正致病突变提供了一个有前途的途径.
  • 在实现高效率和特异性mtDNA编辑方面仍然存在技术障碍.
  • 需要仔细考虑可能出现的非目标编辑和马赛克主义.

结论:

  • 线粒体DNA编辑为预防遗传性疾病提供了线粒体替代的潜在替代方案.
  • 需要进一步的研究和技术进步来确定mtDNA编辑的安全性和有效性.
  • 围绕生殖基因编辑的伦理讨论对于临床翻译至关重要.